晨尿白蛋白/肌酐比值在急性冠脉综合征患者中的临床意义

目的探讨清晨尿白蛋白/肌酐浓度比值(ACR)在急性冠脉综合征(ACS)患者中的临床意义。方法选取79例ACS患者为观察组和健康成人40例为对照组,其中观察组分为不稳定型心绞痛(UAP)组和急性心肌梗塞(AMI)组,分别测定入选者清晨空腹血脂、血糖、C反应蛋白(CRP)及晨尿ACR,比较分析各组间ACR与血脂、血糖、CRP的相关性。结果ACS患者ACR与血糖、低密度脂蛋白、甘油三酯及CRP有明显的正相关(r分别为0.61,0.56,0.63,0.71,P<0.05或0.01),ACS患者ACR水平明显高于正常对照组(P均<0.01)。结论检测ACR水平对临床识别冠状动脉粥样硬化斑块的稳定性、鉴别有心血管危险因素的胸痛患者是否为ACS有一定的临床价值。

Clinical significances of urinary albumin to creatinine ratio in acute coronary artery syndrome

Objective To outline the clinical significances of urinary albumin to creatinine ratio(ACR) in acute coronary syndrome(ACS).Methods 79 patients with ACS were elected in observation group and 40 healthy subjects were chosen in control group,patients in observation group were subdivided into unstable angina pectoris(UAP) group and acute myocardial infarction(AMI) group.In each group,the levels of fasting blood lipid,blood sugar,C-reactive protein (CRP) and urinary ACR were measured and the correction of ACR and blood lipid,blood sugar and CRP were comparatively analyzed.Results In patients with ACS,ACR was positively associated with blood sugar,low density lipoprotein,triglyceride and CRP(r= 0.61,0.56,0.63 0.71,respectively,P<0.05 or 0.01),ACR was higher in patients with ACS,compared to normal subjects(P<0.01).Conclusion ACR can identify the stability of coronary atherosclerosis plaques and confirm whether cardiovascular risk chest pain patients have ACS or not.