血清总IgE、外周血EOS及肺功能在儿童咳嗽变异性哮喘诊断中的价值

目的:探讨血清总IgE、外周血嗜酸性粒细胞(EOS)及肺功能水平检测在儿童咳嗽变异性哮喘(CVA)诊断中的价值。方法:选择CVA发作期、哮喘急性发作期患儿各35例,以及健康对照患儿35例,分别检测3组儿童血清总IgE、外周血EOS绝对值以及肺功能水平,并进行对比分析。结果:CVA组与哮喘组患儿的血清总IgE、外周血EOS绝对值显著高于健康对照组;CVA组与哮喘组患儿EV1%、FEV1/FVC%、PEF%水平虽低于健康对照组,但差异无统计学意义(P>0.05),而FEF25%、FEF50%、FEF75%水平均低于对照组(均P<0.01);吸药后,CVA组与哮喘组患儿FEF25%、FEF50%、FEF75%水平均较吸药前明显改善(均P<0.01),而对照组吸药前、后各指标差异无统计学意义(P>0.05)。结论:对疑似CVA患儿进行血清总IgE、外周血EOS,以及支气管舒张试验检查可有效提高确诊率,且安全快速,适合临床推广应用。

Value of total IgE, EOS and pulmonary function detection in diagnosis of cough variant asthma in children

Objective: To explore the value of total IgE,EOS and pulmonary function detection in diagnosis of cough variant asthma(CVA) in children.Methods : A total of 35 cases of children with CVA and 35 cases with asthma in attack stage were selected,another 35 cases of healthy children were selected as the control group.The levels of serum total IgE,peripheral blood EOS and pulmonary function were detected and analyzed.Results: The levels of total IgE and EOS in CVA group and asthma group were obviously higher than that in control group.The levels of EV1%,FEV1/FVC% and PEF% in CVA group and asthma group were lower than that in control group,but there was no obvious difference.The levels of FEF25%,FEF50% and FEF75% in CVA group and asthma group were obviously lower than that in control group.After inhalation,the levels of FEF25%,FEF50% and FEF75% in CVA group and asthma group obviously improved than that before inhalation,but there was no obvious difference in levels of every index in control group before and after inhalation.Conclusion: The detection of serum total IgE,peripheral blood EOS and pulmonary function in children with suspected CVA can increase the accuracy of diagnosis,and shows high security and safety.It’s worth to be popularized.