| 白花丹醌和亚砷酸对白血病荷瘤小鼠作用的比较。 |
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| 引用本文： | 徐凯红,陆道培.白花丹醌和亚砷酸对白血病荷瘤小鼠作用的比较。[J].海峡药学,2012,24(6):14-16,F0004. |
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| 作者姓名： | 徐凯红 陆道培 |
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| 作者单位： | 1. 浙江宁波市第一医院,宁波,315010
2. 北京道培医院,北京,100049 |
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| 摘 要： | 目的观察白花丹醌对白血病异种移植瘤的体内作用。方法用NB4细胞构建白血病小鼠模型,白花丹醌组(2mg/(kg.d)),亚砷酸组(4mg/(kg.d)),分别腹腔给药15d,计算抑瘤率,凋亡指数(AI)并进行病理组织学检查。结果白花丹醌组抑瘤率为40.49%(P<0.01),AI为(8.52±1.49)%(P<0.01),未出现明显的病理组织损伤。亚砷酸组则无明显的抑瘤作用,凋亡作用不明显(P>0.05),部分伴有心肌组织的损伤。结论 :白花丹醌具有抑制肿瘤生长,诱导凋亡的作用,可能成为白血病治疗的新选择。
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| 关 键 词： | 白花丹醌 亚砷酸 白血病 异种移植瘤 |
Comparison between the effect of Plumbagin and arsenic trioxide on leukemia mice |
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| XU Kai-hong
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LU Dao-pei.Comparison between the effect of Plumbagin and arsenic trioxide on leukemia mice[J].Strait Pharmaceutical Journal,2012,24(6):14-16,F0004. |
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| Authors: | XU Kai-hong LU Dao-pei |
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| Institution: | 1 .Zhejiang Ningbo First Hospital, Ningbo 315010, China;2. Beijing Daopei Hospital, Beijing 100049, China) |
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| Abstract: | OBJECTIVE To observe the effect of Plumbagin in vivo using xenografts mice. METHODS The leukemia mouse model was developed with implantation of NIM cell;plumbagin group （2mg/（kg· d）） and arsenic trioxide group （4mg/（kg· d）） were treated for 15 days by i. p route;suppression of tumor growth and the apop- totic index （AI） were calculated. The histopathologic change was detected. RESUTLS The inhibition rates of plumbagin group was 40.49 % （P 〈 0.01 ）, AI was（8.52 ±1.49） % （P 〈 0.01 ）, and without any obvious patholo- gy of tissue damage.There was no significant effect in arsenic trioxide group except some tissue damage in heart. CONCLUSION Plumbagin may inhibit tumour growth and induce apoptosis, can be a new choice for leubemia treatment. |
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| Keywords: | Plumbagin Arsenic trioxide Leukemia Xenograft |
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