吉西他滨+卡铂对比泰素(TB)治疗复发卵巢上皮癌的临床疗效观察

目的研究吉西他滨+卡铂治疗复发性上皮性卵巢癌的疗效和毒性。方法实验组:27例复发性上皮性卵巢癌应用吉西他滨1000mg/m2,第一、八天静脉滴注,曲线下面积=5,第一天静脉滴注。对照组:31例复发性上皮性卵巢癌应用紫杉醇175mg/m2,第一天静脉滴注,卡铂曲线下面积=5。第一天静脉滴注。每21天为一个疗程,坚持化疗3~12个疗程。分析两组之间的治疗效果以及毒副反应,探讨两组肿瘤患者的生活质量情况。结果实验组总有效率为77.8%,其中完全有效(26.0%),部分有效(51.9%),中位无进展生存4.2个月(2~10个月);对照组ORR为48.4%,其中完全有效(12.9%),部分有效(35.5%),位无进展生存为2.8个月(2~13个月),两组有显著差异。两组毒副反应均为骨髓抑制,对照组还以过敏反应为显著,导致4例终止疗程。对照组较实验组明显加剧其毒副反应,差异有显著意义。在肿瘤患者的生活质量评分中,实验组81.5%>50分,而对照组只有35.5%,差异有显著性。结论在治疗复发性复发性上皮性卵巢癌中,吉西他滨+卡铂较紫杉醇方案更为有效,安全性更高,毒副反应更轻,对患者的生活质量影响更少。

Clinical observation of Gemeitabine plus carboplatin compard TB when in treantment of recurrent epithelial ovarian cancer

OBJECTIVE To Study the efficacy and toxicities of Gem ＋ CBP for patients with recurrent EOC. METHODS experimental group 27 cases of recurrent EOC received GEM（ 1000mg/m2, dl, d8 iv）plus CBP （AUC= 5. dl iv）of each 21 day cycle. Control group：31 cases of recurrent EOC received Taxol（175mg/m2, dl iv） puls CBP （AUC= 5, dl iv） of each 21 day cycle, insist on 3-12 cycles. Analysis the efficacy and toxicities of the two groups. RESULTS Of the 27 female patients enrolled, the ORR was 77.89G, with CR （26.0 % ）, PR（51.9%）, PFS was 4.2 months （2-10 months）; control group ORR was 48.4%, with CR （12.9%）, PR （35.5 % ）, PFS was 2.8 months （2-13 months）, significant differences between the two groups. The most toxicity were bone marrow suppression, such as neutropenia and thrombocytopenia, Allergic reactions was another significant reaction in control group and four cases＇s therapies wer terminated. The control group＇s toxicity was more serious than the experimental group＇s.The QOL of 81.5 % paitents in expermental group were more than 50 point while the other were 35.5 %. CONCLUSION To treat recurrent EOC, Gem ＋ CBP is more effective, moresecure than TC. Its toxicity is lighter and less impact on the quality of life of patients.