甲状腺癌与甲状腺球蛋白抗体的关系研究

目的:探讨血清甲状腺球蛋白、甲状腺球蛋白抗体与分化型甲状腺癌的关系。方法:将我院收治的42例分化型甲状腺癌患者作为研究1组,56例甲状腺良性病变患者作为研究2组,同时选取我院50例门诊体检健康志愿者作为对照组,采用放射免疫分析法检测3组血清甲状腺球蛋白、甲状腺球蛋白抗体表达情况。对研究1组患者进行治疗,观察治疗前后研究1组患者血清甲状腺球蛋白、甲状腺球蛋白抗体的变化。结果:研究1组甲状腺球蛋白阳性表达率及甲状腺球蛋白抗体阳性表达率明显高于研究2组和对照组,数据间差异有统计学意义(P<0.05);研究2组甲状腺球蛋白阳性表达率与对照组无显著差异(P>0.05);治疗后研究1组患者血清甲状腺球蛋白、甲状腺球蛋白抗体水平明显下降,与治疗前相比差异有统计学意义(P<0.05)。结论:甲状腺球蛋白、甲状腺球蛋白抗体可以用于评价分化型甲状腺癌的治疗疗效。

Relationship between serum thyroglobulin, thyroglobulin antibodies and differentiated thyroid cancer

Objective: To investigate the relationship between serum thyroglobulin,thyroglobulin antibodies and differentiated thyroid cancer.Methods: A total of 42 patients of differentiated thyroid cancer served as study group 1,56 patients of benign thyroid disease served as study group 2,and 50 healthy volunteers served as control group.Serum thyroglobulin,thyroglobulin antibody of three groups was determined by using radioimmunoassay assay.Results:Positive expression of thyroglobulin and thyroglobulin antibody was significantly higher in study group 1 than these of study group 2 and control group(P<0.05);there was no significant difference in positive expression of thyroglobulin between study group 2 and the control group(P>0.05).After treatment,serum thyroglobulin and thyroglobulin antibody levels were significantly decreased in study group 1(P<0.05).Conclusions: Thyroglobulin and thyroglobulin antibodies can be used for efficacy evaluation of differentiated thyroid cancer therapy.