| 高效液相色谱法测定米非司酮片的含量和含量均匀度 |
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| 引用本文： | 罗亚虹,陈莹,唐娟娟. 高效液相色谱法测定米非司酮片的含量和含量均匀度[J]. 海峡药学, 2012, 24(4): 52-54 |
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| 作者姓名： | 罗亚虹 陈莹 唐娟娟 |
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| 作者单位： | 广西桂林食品药品检验所,桂林,541002 |
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| 摘 要： | 目的建立高效液相色谱法测定米非司酮片的含量和含量均匀度的方法。方法采用Zorbax XDB C18色谱柱(250mm×4.6mm,5μm),流动相为甲醇-水-三乙胺(75∶25∶0.05),流速1.0mL·min-1,检测波长为306nm。结果米非司酮在1.0979～43.916μg·mL-1(r=0.9999)范围内具有良好的线性,回收率为100.03%,RSD为0.22%。结论该方法操作简便,结果准确,重现性好,可用于米非司酮片的质量控制。
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| 关 键 词： | 高效液相色谱法 米非司酮片 含量 含量均匀度 |
Determination of content and its evenness in Mifepristone tablets by HPLC |
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| LUO Ya-hong , CHEN Ying , TANG Juan-juan. Determination of content and its evenness in Mifepristone tablets by HPLC[J]. Strait Pharmaceutical Journal, 2012, 24(4): 52-54 |
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| Authors: | LUO Ya-hong CHEN Ying TANG Juan-juan |
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| Affiliation: | (Guangxi Guilin institute for food and drug control,Guilin 541002,China) |
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| Abstract: | OBJECTIVE To establish a method for component and its evenness of Mifepristone tablets by HPLC.METHODS The HPLC was performed with C18 column（250mm×4.6mm,5μm）,and the mobile phase consisted of Methanol-water-three ethylamine-glacial acetic acid（75∶25∶0.05）;at flow rate of 1.0mL·min-1.The UV detective wavelength was 306 nm.RESULTS Mifepristone well showed linear relationship within the range of 1.0979～43.916μg·mL-1（r=0.9999）.The recovery rate was 100.03% and the RSD was 0.22%.CONCLUSION The method is simply operated with accurate and reliable results.It is available for the quality control of the Mifepristone tablets. |
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| Keywords: | HPLC Mifepristone tablets content content evenness |
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