胎儿生长受限患者sFlt-1、PLGF的表达及其意义

目的:观察胎儿生长受限患者血清可溶性血管内皮生长因子受体-1(sFlt-1)、胎盘生长因子(PL-GF)的表达及其意义。方法:30例胎儿生长受限患者作为实验组,同期住院的30例正常孕妇作为对照组,住院当天留取两组孕妇的血清标本,用ELISA法检测血清中sFlt-1、PLGF的水平,并进行比较。结果:实验组、对照组的PLGF水平分别为(1 462.39±364.51)、(2 685.05±322.61)pg/mL,sFlt-1水平分别为(9 509.67±1 406.91)、(4 103.42±661.82)pg/mL,两组PLGF、sFlt-1水平差异均有统计学意义(P<0.05)。结论:FGR时孕妇血清sFlt-1升高、PLGF下降,sFlt-1、PLGF可考虑作为胎儿生长受限的筛查指标。

Expression of sFlt-1, PLGF in patients suffering from fetal growth restriction and its clinical significance

Objective: To explore the expression of solube vascular endothelial growth factor receptor-1(sFlt-1)、placental growth factor(PLGF) in patients suffering from fetal growth restriction and its clinical significance.Methods: A total of 30 cases of pregnant women with fetal growth restriction were enrolled as experimental group and 30 cases of healthy pregnant women hospitalized during the same period were also enrolled as control group.Maternal serum levels of sFlt-1、PLGF measured by ELISA method were compared between the two groups.Results: The serum levels of sFlt-1 and PLGF in the experiment group and control group were(1 462.39±364.51)pg/mL vs.(2 685.05±322.61)pg/mL and(9 509.67±1406.91)pg/mL vs.(4 103.42±661.82)pg/mL showing significant difference between the two groups(P<0.05).Conclusions: PLGF level decreased and sFlt-1 increased in patients suffered from fetal growth restriction,thus they can be indicator of the fetal growth restriction.