| 复方米诺环素过氧化苯甲酰洗剂的制备及质量控制 |
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| 引用本文： | 李成,李婷,巫小娟,冯廉洁.复方米诺环素过氧化苯甲酰洗剂的制备及质量控制[J].海峡药学,2012,24(7):22-24. |
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| 作者姓名： | 李成 李婷 巫小娟 冯廉洁 |
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| 作者单位： | 广东深圳市福田人民医院,深圳,518033 |
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| 摘 要： | 目的制备以米诺环素和过氧化苯甲酰为主药的复方外用洗剂,并建立其质量控制方法。方法采用紫外分光光度法测定米诺环素的含量,测定波长352nm;间接碘量法测定过氧化苯甲酰的含量。结果米诺环素的检测线性范围为4~24μg.mL-1,r=0.9998,平均回收率为100.2%;过氧化苯甲酰的平均回收率为99.6%,RSD为0.6%(n=6)。结论该制剂制备工艺简单、质量稳定,质量控制方法可行。
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| 关 键 词： | 复方米诺环素过氧化苯甲酰洗剂 制备 质量控制 紫外分光光度法 间接碘量法 |
Preparation and quality control of compound minocycline Benzoperoxide Lotion |
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| LI Cheng
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LI-Ting
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WU Xiao-juan
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FENG Lian-jie.Preparation and quality control of compound minocycline Benzoperoxide Lotion[J].Strait Pharmaceutical Journal,2012,24(7):22-24. |
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| Authors: | LI Cheng LI-Ting WU Xiao-juan FENG Lian-jie |
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| Institution: | (The People＇s Hospital of Futian, Shenzhen, 518033, China) |
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| Abstract: | OBJECTIVE To prepare Compound minocyeline Benzoperoxide Lotion and to establish its quali ty control method.METHODS UVSpeetrophotometry（k352） was used to determine the content of minoey eline;indireet iodometrie was used to deterrn the content of Benzoperoxide.RESULTS The test of minoeyeline concentration was linear within the range of 4-24μg·mL-1. r = 0. 9999. The average recovery was 100.2 % ;The average recovery of Benzoperoxide was 99.6 %, RSD = 0.6 % （n = 6）. CONCLUSION The preparation technolo gy is simple and feasible, and its quality is stable and controllable. |
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| Keywords: | Compound Minocycline Benzoperoxide Lotion Preparation Quality control UV Spectrophotometry Indirect iodomet- |
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