乙肝免疫球蛋白阻断乙肝病毒母婴传播效果研究

目的:分析乙肝免疫球蛋白对于阻断乙肝病毒母婴传播的效果。方法:病例选自我科室门诊2010年1月～2011年3月接受孕期检查的HBV携带的132例孕妇,大三阳和小三阳的孕妇于孕24周开始接受HBIG注射治疗,携带者孕妇于孕28周开始接受HBIG注射。结果:孕24周与分娩前的乙肝标志物与HBV-DNA检查结果无显著差异(P>0.05)。HBIG阻断HBV母婴传播疗效,总有效率为75.71%。而HBIG阻断HBV疗效大三阳孕妇较携带者和小三阳孕妇疗效不佳,存在明显差异。新生儿接受疫苗接种和HBIG注射后12个月,HBsAb(+)率为86.43%,与新生儿出生时HBsAb(+)率75.71%相比,有较大改善。结论:对HBV感染的孕妇在孕24周后注射HBIG,阻断乙肝病毒母婴传播效果明显,新生儿出生后采用HBIG和HBV疫苗联合阻断HBV母婴传播临床效果显著。

Hepatitis b immunoglobulin for blocking the hepatitis b virus mother-to-child transmission

Objective: To analyze the effects of hepatitis b immunoglobulin for blocking the hepatitis b virus mother-to-child transmission.Methods:A total of 132 cases pregnant women that confirmed as HBV carrier that visited our hospital during January 2010 and March 2011 were enrolled in this study,those shown HBsAg,HBeAg and Anti-HBc positive or HBsAg,Anti-HBe and Anti-HBc positive started to get HBIG injection from the 24th week of pregnancy,while HBV carriers started on the 28th week of preganancy.Results:Efficiency of HBIG blocking HBV mother-to-child transmission was 75.71%.But the efficiency of HBIG for blocking HBsAg,HBeAg and Anti-HBc positive or HBsAg,Anti-HBe and Anti-HBc positive pregnant women was different.For new born infants,after injection of HBIG,86.43% were shown as HBsAb(+),which is improved comparing with the 75.71% before injection.Conclusions: After injection of HBIG on the 24th week of pregnancy,effects of blocking the hepatitis b virus mother-to-child transmission in pregnant women with HBV infection is obvious,for new born infants,HBIG combing with HBV is effective on blocking HBV mother-to-child transmission.