血浆B型脑钠肽在急性呼吸道感染合并心衰患者诊断中的意义

目的:探讨血浆B型脑钠肽对急性呼吸道感染合并心力衰竭诊断中的意义。方法:将我院收治的急性呼吸道感染合并心力衰竭的患者32例作为研究1组,未合并心力衰竭的急性呼吸道感染患者40例作为研究2组,同时选取30例健康人作为对照组,应用免疫荧光法测定3组中血浆B型脑钠肽的含量,采用酶联免疫吸附法测定3组肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)的水平。结果:(1)研究1组、研究2组TNF-α及IL-8水平明显升高,与对照组相比有统计学意义(P<0.01);研究1组与研究2组TNF-α及IL-8水平无统计学差异(P>0.05);(2)研究1组血浆B型脑钠肽水平明显高于研究2组及对照组,数据间差异有统计学意义(P<0.01)。结论:急性呼吸道感染合并心力衰竭的患者血浆B型脑钠肽水平明显升高,检测血浆B型脑钠肽可以为急性呼吸道感染合并心力衰竭提供诊断依据。

Significance of B-type natriuretic peptide testing in patients with acute respiratory infections complicated with heart failure

Objective: To investigate the significance of B-type natriuretic peptide testing in patients of acute respiratory infections complicated with heart failure.Methods:A total of 32 patients of acute respiratory infections complicated with heart failure were enrolled as study group 1,40 patients with acute respiratory infections as study group 2;30 healthy volunteers were also enrolled as control group.B-type natriuretic peptide plasma levels were detected with immune fluorescence spectrometry,tumor necrosis factor-α(TNF-α) and interleukin-8(IL-8) levels were also detected by enzyme-linked immunosorbent assay.Results: ①TNF-α and IL-8 levels of study group 1 and study group 2 were significantly elevated compared with the control group(P<0.01);but TNF-α and IL-8 levels of study group 1 and study group 2 were not significantly different(P>0.05).② Study group 1 showed significant higher BNP levels than study group 2 and control group(P<0.01).Conclusions: B-type natriuretic peptide level is elevated in patients of acute respiratory infections complicatted with heart failure,thus serum B-type natriuretic peptide detecting can be evidence for the diagnosis of the disease.