慢性肾脏病患者血浆iPTH检测的临床价值

目的:探讨慢性肾脏病患者血浆iPTH检测的临床应用价值。方法:收集124例慢性肾脏病患者及30例健康者作为对照组,检测空腹血清尿素氮、肌酐、钙、磷和血浆全段甲状旁腺素(intact para-thyroid hormone,iPTH)水平,采用MDRD公式计算肾小球滤过率(glomerulate filtration rate,GFR),Pearson相关分析血浆iPTH水平与GFR、尿素氮和肌酐关系。结果:(1)慢性肾脏病患者血清钙、磷和iPTH水平均存在异常,组间比较差别具有统计学意义(P<0.05);(2)Pearson相关分析结果显示慢性肾脏病患者血浆iPTH水平与血清尿素氮和肌酐水平均呈正相关,与GFR呈负相关。结论:慢性肾脏病患者血浆iPTH水平均升高,且与GFR呈负相关,检测血浆iPTH水平不但能够反应患者钙磷代谢水平,还能够反应肾功能下降程度。

Clinical application of iPTH detection in diagnosis of chronic kidney disease

Objective: To investigate the clinical application of iPTH detection in diagnosis of chronic kidney disease.Methods:A total of 124 patients with chronic kidney disease served as experimental group and 30 cases severed as control group.Fasting serum were used to evaluate the serum levels of blood urea nitrogen(BUN),creatinine(Cr),calcium(Ca),phosphorus(P),plasma intact parathyroid hormone(iPTH),and glomerulate filtration rate(GFR) was calculated with the formulation of MDRD.Relationship of plasma level of iPTH with GFR and serum levels of BUN and Cr were analyzed by Pearson correlation analysis.Results:(1)The levels of Ca,P and iPTH were abnormal in patients with chronic kidney disease,and there were significant differences in these parameters among these groups(P<0.05),(2) plasma level of iPTH was positively correlated with serum levels of BUN and Cr in patients with chronic kidney disease and negatively correlated with GFR according to Pearson correlation analysis.Conclusion:Plasma level of iPTH increases in patients with chronic kidney disease and has negative correlation with GFR.Plasma level of iPTH detection could be used to indicate the abnormality of Ca and P and could also reflect the impairment of renal function.