左氧氟沙星与3种药物配伍的稳定性

目的:探讨左氧氟沙星分别与地塞米松磷酸钠、维生素C、庆大霉素配伍的稳定性。方法:将左氧氟沙星分别与地塞米松磷酸钠、维生素C、庆大霉素按临床常用量配伍,然后在配伍后的即时、1h、4h和6h分别对3种配伍进行观察外观及测定pH值、不溶性微粒、左氧氟沙星及配伍药物的含量。结果:左氧氟沙星与维生素C或地塞米松磷酸钠或庆大霉素配伍,其颜色、pH值、不溶性微粒及药物含量均无明显变化。结论:乳酸左氧氟沙星可以与地塞米松磷酸钠、维生素C、庆大霉素混合输注,不产生不良反应。

Stability of compatibility of levofloxacin and three kinds of drug

Objective: To observe stability of compatibility of levofloxacin with sodium dexamethasone,vitamin C,gentamycin,respectively.Methods:The compatibility of levofloxacin and dexamethasone sodium phosphate,sodium phosphate,vitamin C,gentamycin were made at regular clinical dosage.And appearance,pH value,insoluble particles,content level were observed and determined immediately after compatibility,1 h,4 h and 6 h later,respectively.Results:Levofloxacin was compatible with vitamin C,dexamethasone sodium or gentamycin compatibility.There was no change in color,pH value,insoluble particles and content level.Conclusions:Lactic acid levofloxacin can be used with dexamethasone sodium phosphate,sodium phosphate,vitamin C,and gentamycin,and no adverse reaction will occur.