Modification of the level of acetylcholinesterase activity by two oximes in certain brain regions and peripheral tissues of paraoxon treated rats

The effect of two oximes, 2-PAM and DAM, on the level of acetylcholinesterase activity in certain brain regions and peripheral tissues of paraoxon treated rats was determined. Both the oximes induced the reactivation of cortical and striatal oholinesterase activity which may be related to certain central effects of oximes. The effect of DAM was significantly greater than 2-PAM. In peripheral tissues- liver, diaphragm and triceps, the values of cholinesterase in paraoxon-DAM treated animals were slightly but significantly higher than the corresponding values in paraoxon- 2-PAM treated animals.