福建省2003-2015年儿童HIV/AIDS病例生存时间分析

目的 探讨福建省儿童艾滋病病毒感染者/获得性免疫缺乏综合症（HIV/AIDS）病例生存时间及影响因素。方法 选择2003年1月1日-2015年12月31日福建省新发现的儿童HIV/AIDS病例，收集病例的全死因死亡信息，计算儿童HIV/AIDS病例的生存率。结果 福建省2003-2015年累计发现儿童HIV/AIDS病例67例，感染途径均为母婴传播。报告死亡病例17例，全死因死亡率7.34/100人年。儿童HIV/AIDS病例平均生存时间为102月（95%CI=84~120），第1、2、3、4、5和10年的累计生存率分别为84%、80%、80%、77%、71%和56%。儿童AIDS病人死亡风险是儿童HIV感染者的8.089（95%CI=1.826~35.841）倍，未接受抗病毒治疗病例死亡风险是接受抗病毒治疗病例的13.330（95%CI=3.749~47.396）倍。结论 福建省新发现的儿童HIV/AIDS病例数呈逐年缓慢上升，应进一步加强产妇孕产期HIV抗体工作和综合干预。

Survival of children with HIV/AIDS in Fujian province, 2003-2015

Objective To explore the survival time and its related factors among children with human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS) in Fujian province.Methods All children newly identified with HIV/AIDS during the period between January 1,2003 and December 31,2015 were recruited for the study.We collected detailed information on death of the children to calculate the survival time;univariate and multivariate analysis were used to explore the factors related to the survival of the children.Results A total of 67 children with HIV/AIDS due to mother-to-child transmission were reported and 17 of them died,with an all-cause mortality rate of 7.34/100 person years during the 14-year period in Fujian province.The mean survival time for the children with HIV/AIDS was 102 months (95 confidence interval [95%CI]=84-120) and the cumulative survival rate at the end of 1st,2nd,3rd,4th,5th and 10th year after the confirmation of HIV antibody positive were 84%,80%,80%,77%,71%,and 56%,respectively.Cox regression analysis indicated that the death hazard of the children with AIDS was 8.089 (95%CI:1.826-35.841) times higher compared to those with HIV and the death hazard of the children without antiretroviral therapy (ART) was 13.330 (95%CI:3.749-47.396) times higher than the children with ART.Conclusion The number of newly reported children with HIV/AIDS increased slowly year by year in Fujian province,suggesting that HIV antibody test and comprehensive intervention among pregnant women should be strengthened.