MMP-9在宫颈鳞癌组织中的表达和意义

目的 探讨基质金属蛋白酶MMP-9与宫颈鳞癌的发生、发展及转移的关系.方法 免疫组化SP法测定MMP-9的表达及分布.结果 在宫颈鳞癌组织(SCC)和重度鳞状上皮细胞内损害(HSIL)中MMP-9蛋白的表达量均高于轻度鳞状上皮细胞内损害(LSIL) (P＜0.01,P＜0.05);宫颈鳞癌组织中淋巴结转移组MMP-9的阳性率(78.3%)显著高于无淋巴结转移组(63.3%),P＜0.01;MMP-9的表达在不同的病理分级与临床分期之间差异无显著性.结论 MMP-9与宫颈鳞癌的早期浸润及转移有关,MMP-9表达量的增高有助于临床医师正确评估病人的预后并制定适当的临床治疗方案.

Expression of MMP-9 and their Clinical Significance in Cervical Carcinoma

Objective To investigate the relationship between the expression of matrix metalloproteinases-9(MMP-9) and tumorigenesis,development and metastasis of cervical squamous carcinoma.Methods The expression and distribution of MMP-9 proteins were detected by using immunohistochemical S-P method.The relationship between those indexes and the factors related to clinical pathology of cervical carcinoma were analyzed statistically.Results Immunohistochemical studies demonstrated that MMP-9 were expressed in 69.8% of squamous cell carcinomas(SCC) and 47.6% of high-grade squamous intraepithelial lesions(HSIL),but were less frequently expressed in Low-grade squamous intraepithelial lesions(LSIL)(10%)Results.In squamous cell carcinomas,MMP-9 protein was expressed in 78.30% of patients that positively correlated with lymphatic metastasis significantly(P<0.05).And the expressions of MMP-9 were not significantly related to the grade,stage status.Conclusion MMP-9 are related well with initial invasion and metatasis of cervical squamous carcinoma.Conclusion The positive expressions of MMP-9 can be used to estimate the metastatic potentiality and help for the adjuvant treatment.