| 人错配修复基因2、细胞增殖核抗原在宫颈癌组织中的表达及意义 |
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| 引用本文： | 徐又先,姚冬梅,濮德敏.人错配修复基因2、细胞增殖核抗原在宫颈癌组织中的表达及意义[J].华中科技大学学报(医学版),2006,35(3):339-342. |
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| 作者姓名： | 徐又先 姚冬梅 濮德敏 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院妇产科,武汉,430030 |
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| 摘 要： | 目的 研究判定宫颈癌患者预后的分子生物学指标。方法 通过免疫组织化学方法 观察人错配修复基因2（hMSH2）、细胞增殖核抗原（Ki-67）在宫颈鳞癌、腺癌组织中的表达。结果 在宫颈癌组织中hMSHz、Ki-67阳性表达率高于正常宫颈组织（均P〈0．01）；hMSH2高表达与宫颈癌淋巴结转移、癌细胞分化程度密切相关（均P〈0．05）；hM-SH2表达阳性者Ki-67表达强度明显高于hMSH2表达阴性者（P〈0．05）。结论 hMSH2、Ki-67可能参与宫颈癌的发生、发展及转移过程，hMSH2在宫颈癌中的过表达与细胞增殖密切相关。
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| 关 键 词： | 子宫颈癌 细胞增殖核抗原 人错配修复基因2 免疫组织化学 |
| 修稿时间： | 2005年4月25日 |
hMSH2 and Ki-67 Antigen Expression in Cervical Cancer and Its Significance |
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| Xu Youxian,Yao Dongmei,Pu Demin.hMSH2 and Ki-67 Antigen Expression in Cervical Cancer and Its Significance[J].Journal of Huazhong University of Science and Technology(Health Sciences),2006,35(3):339-342. |
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| Authors: | Xu Youxian Yao Dongmei Pu Demin |
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| Abstract: | Objective To study the molecular biological criterion evaluating the prognosis of patients with cervical cancer.Methods The expression of hMSH_2 and Ki-67 was detected in squamous cell carcinoma and adenocarcinoma by using immunohistochemical staining.Results The expression of hMSH_2 and Ki-67 in cancer cells was significantly higher than that in control group(P<0.01).Overexpression of hMSH_2 in cervical carcinoma was related to lymph node metastasis and differentiation degree(P<0.05).The expression of Ki-67 was significantly higher in the hMSH_2-positive tumors than in the negative ones(P<0.05).Conclusion The expression of hMSH_2 and Ki-67 might play an important role in carcingensis,development and metastasis of cervical carcinoma.Its overexpression is also closely related with tumor cell proliferation. |
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| Keywords: | cervical carcinoma Ki-67 antigen human mismatch repair gene 2 immunohistochemistry |
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