c-Fos expression in the supraoptic nucleus is the most intense during different durations of restraint water-immersion stress in the rat |
| |
Authors: | Yu-Yu Zhang Wen-Xing Zhu Guo-Hong Cao Xi-Yun Cui and Hong-Bin Ai |
| |
Institution: | (1) Key Laboratory of Animal Resistance of Shandong Province and College of Life Sciences, Shandong Normal University, 250014 Jinan, People’s Republic of China;(2) College of Life Sciences, Shandong Normal University, Shandong Province, 250014 Jinan, People’s Republic of China |
| |
Abstract: | Restraint water-immersion stress (RWIS) can induce anxiety, hypothermia, and severe vagally-mediated gastric dysfunction.
The present work explored the effects of different durations of RWIS on neuronal activities of the forebrain by c-Fos expression
in conscious rats exposed to RWIS for 0, 30, 60, 120, or 180 min. The peak of c-Fos induction was distinct for different forebrain
regions. The most intense c-Fos induction was always observed in the supraoptic nucleus (SON), and then in the hypothalamic
paraventricular nucleus (PVN), posterior cortical amygdaloid nucleus (PCoA), central amygdaloid nucleus (CeA), and medial
prefrontal cortex (mPFC). Moreover, body temperature was reduced to the lowest degree after 60 min of RWIS, and the gastric
lesions tended to gradually worsen with the prolonging of RWIS duration. These data strongly suggest that these nuclei participate
in the organismal response to RWIS to different degrees, and may be involved in the hypothermia and gastric lesions induced
by RWIS. |
| |
Keywords: | c-Fos expression Supraoptic nucleus Restraint water-immersion stress Gastric lesions Hypothermia |
本文献已被 SpringerLink 等数据库收录! |
|