普拉克索治疗帕金森病的临床疗效观察

目的 观察普拉克索治疗帕金森病的临床疗效.方法 对40例帕金森病病人进行统一评分量表(UPDRS)评分,其中6例病人未服用任何抗帕金森药物即予普拉克索治疗,其余病人在原药基础上加服普拉克索.用药12周后再次应用UDPRS量表进行评分.比较普拉克索治疗前后UDPRS量表分值的差异.部分帕金森病人采用2周,4周,8周,12周随访,对病情进行评分,来观察疗效.结果 40例病人经普拉克索治疗后,有效35例,有效率87.5%.治疗前后,大部分帕金森患者在UDPRS总评分、日常活动、运动功能、震颤、肌僵直、精神症状、开关现象等方面的评分改善均有统计学意义.而且对部分门诊病人的随访评分中发现,病人的各方面病情也有很大的好转.结论 普拉克索可有效改善帕金森病人的临床症状,是一种使用安全、疗效理想的抗帕金森病药物.

Therapeutic effect of pramipexole in Parkinson's disease

Objective To study the therapeutic effect of pramipexole in Parkinson's disease (PD). Methods Forty patients with PD were treated with pramipexole for 12 weeks and evaluated with Unified Parkinson's Disease Rating Scale (UPDRS) before and after therapy.Among them, 6 cases were treated with pramipexole without any anti-PD drugs, and the rest with pramipexole and other anti-PD drugs. Some cases received follow-up at week 2, 4, 8, 12 to evaluate the therapeutic effect.Results After the therapy ofpramipexole, the symptoms of PD were alleviated in 35 patients (87.5％).The alleviation was statistically significant in UPDRS scores, daily activities, motor function, trembling,splinting, mental symptoms and on-off phenomenon.Futhermore, the post-therapeutic follow-up revealed that the patients get much better. Conclusions Pramipexole is effective in the treatment of PD.It is a safety and good effctive anti-parkinson drug.