An empirical test of the two-threshold model of disease transmission |
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Authors: | D. PAULS S. SINGER |
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Affiliation: | Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242;Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309 |
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Abstract: | Recent research on diabetes mellitus has revealed the existence of at least two independent subtypes. The multifactorial analysis method suggested by Reich & co-workers (1972) for testing the independence of transmission between subtypes of a complex disorder agrees with this distinction. These techniques were also sensitive to the non-unitary nature of the mental retardation within a sample of subjects drawn from the data set of Reed & Reed (1965). Therefore, we believe that this analysis could be a valuable adjunct to the limited repertoire of methods currently available to psychiatric researchers for dealing with issues of differential diagnosis. |
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