心力衰竭患者血清NT-proBNP、hs-CRP和ALD的联合检测意义研究

目的探讨心力衰竭（HF）患者血清N端B型脑钠肽（NT-proBNP）、超敏C反应蛋白（hs-CRP）和醛固酮（ALD）的联合检测意义。方法选择我院心力衰竭患者共50例,根据美国纽约心脏协会（NYHA）制定的心功能分级标准：Ⅲ级患者24例,Ⅳ级别患者26例。同时选择我院同期健康体检者50例,作为对照组。上述所选对象均取清晨空腹静卧位肘静脉血,测定血清NT-proBNP、hs-CRP和ALD水平。结果心功能Ⅲ患者和心功能Ⅳ级患者NT-proBNP、hs-CRP和ALD水平均显著高于对照组,差异有统计学意义（P〈0.01）;心功能Ⅳ级患者血清NT-proBNP、hs-CRP和ALD水平均显著高于心功能Ⅲ患者,差异有统计学意义（P〈0.01）。冠心病患者血清hs-CRP水平显著高于扩张型心肌病和高血压心脏病患者,差异有统计学意义（P〈0.01）,而扩张型心肌病和高血压心脏病患者之间血清hs-CRP水平差异无统计学意义（P〉0.05）;冠心病、扩张型心肌病和高血压心脏病患者之间,血清NT-proBNP和ALD水平差异无统计学意义（P〉0.05）。结论 NT-proBNP、ALD和hs-CRP联合检测有助于了解心力衰竭患者的病因及其严重程度,并为临床治疗提供帮助。

Study on the combined detection of serum NT-proBNP,hs-CRP and ALD in patients with heart failure

Objective To investigate the significance of combined detection of serum N -terminal pro-brain natriuretic peptide（NT-proBNP）,high sensitive c-reactive protein（hs-CRP） and aldosterone（ALD） in patients with heart failure（HF）. Methods According to New York Heart Association（NYHA） developed cardiac function grading criteria, we choosed 24 patients with class III,26 patients with class IV and 50 healthy controls. All aboved subjects were detected the level of serum NT-proBNP、hs-CRP and ALD. Results The level of serum NT-proBNP、hs-CRP and ALD in both class III patients and class IV patients were significantly higher than those of the control group （P0.01）.The level of serum NT-proBNP,hs-CRP and ALD in class IV patients were obviously elevated comparing with class III patients （P0.01）.The level of serum hs-CRP in patients with coronary heart disease was significantly higher than those of patients with dilated cardiomyopathy and hypertensive heart disease （P0.01）, while the level of serum hs-CRP were no significant difference between dilated cardiomyopathy patients and hypertensive heart disease patients （P0.05）,the level of serum NT-proBNP and ALD were no significant difference among the three （P0.05）. Conclusion The allied detection of serum NT-proBNP,hs-CRP and ALD contribute to understand the pathogeny of HF and provide assistance for clinical treatment.