|
|||||
|
|
| 电子自旋共振和脂质过氧化对亚硒酸钠诱发大鼠白内障的自由基作用研究 | |
| 引用本文： | 徐茜人,胡新珉,张书琴,陈继镛,冯家珉. 电子自旋共振和脂质过氧化对亚硒酸钠诱发大鼠白内障的自由基作用研究[J]. 四川大学学报(医学版), 1999, 30(3): 15 |
| 作者姓名： | 徐茜人 胡新珉 张书琴 陈继镛 冯家珉 |
| 作者单位： | 1. 华西医科大学口腔医学院,卫生部口腔生物医学工程重点实验室,成都,610041 2. 华西医科大学,基础医学院,物理学教研室 3. 四川大学,分析测试中心 |
| 摘 要： | 以 Ｎａ２ Ｓｅ Ｏ３ 诱发大鼠白内障，用 Ｅ Ｓ Ｒ 波谱仪测到了自由基信号（ｇ＝ ２．００２６），发现注射 Ｎａ２ Ｓｅ Ｏ３后晶体自由基浓度显著高于正常水平，而白内障后期低于晶体正常水平。结果提示，在晶体氧化损伤初期给予抗氧化剂，对白内障的形成有预防和对抗作用，但是在白内障晚期则可能会促进白内障的发展。 |
| 关 键 词： | 电子自旋共振 脂质过氧化 白内障 自由基 |
Free Radicals on Cataracts Induced by Sodium Selenite Studied by ESR and LPO |
|
| Xu Qianren,Hu Xinmin,Zhang Shuqin,Chen Jinyong,Feng Jiamin. Free Radicals on Cataracts Induced by Sodium Selenite Studied by ESR and LPO[J]. Journal of Sichuan University. Medical science edition, 1999, 30(3): 15 | |
| Authors: | Xu Qianren Hu Xinmin Zhang Shuqin Chen Jinyong Feng Jiamin |
| Abstract: | We made a electron spin resonance (ESR) study on rat cataracts induced by Na 2SeO 3. A signal was detected at about g=2.0026, and the content of electron spins (CES) in lens of rat administrated Na 2SeO 3 for a short time is higher than that of control significantly. At the late stage of cataracts, the content of CES was lower than normal level. The results of kinetics analysis showed that the CES grow up with the administration of Na 2SeO 3 and decays in index law after administration. The results suggested that free radical scavengers or anti oxidants should be useful for preventing cataracts at initial stage of the oxidation damage to lens, but they could aggravate cataracts at late stage of cataracts. This can explain the controversy about the curative effect of anti oxidant to cataracts. |
| Keywords: | Electron spin resonance (ESR) Lipid peroxidation (LPO) Cataract Free radicals |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |