利妥昔单抗联合大剂量甲氨蝶呤在原发性中枢神经系统淋巴瘤患者中的应用效果

目的 探讨利妥昔单抗联合大剂量甲氨蝶呤在原发性中枢神经系统淋巴瘤患者中的应用效果.方法 按照入院顺序将84例原发性中枢神经系统淋巴瘤患者分为对照组和观察组,每组42例,对照组接受大量甲氨蝶呤治疗,观察组患者接受利妥昔单抗联合大剂量甲氨蝶呤治疗.比较两组患者的临床疗效、不良反应、生存期和生活质量.结果 观察组患者的治疗总...

Effect of rituximab combined with high-dose methotrexate in patients with primary central nervous system lymphoma

Objective To investigate the efficacy of rituximab combined with high-dose methotrexate in patients with primary central nervous system lymphoma.Method According to the order of admission,84 patients with primary central nervous system lymphoma were divided into control group and observation group,with 42 patients in each group.The control group received high-dose methotrexate treatment,while the observation group received rituximab combined with high-dose methotrexate treatment.The clinical efficacy,adverse reactions,survival time and quality of life of the two groups were compared.Result The total effective rate of treatment in the observation group was 71.43%,which was higher than 50.00%in the control group,and the difference was statistically significant(P<0.05).Before treatment,comparison of generic quality of life inventory-74(GQOLI-74)scale scores in all dimensions between the two groups showed no statistically significant difference(P>0.05).After treatment,the total scores of material life,physical function,social function,psychological function and quality of life in the two groups were higher than those in the control group(P<0.05).The patients were followed up for 3 years,the survival time of patients in the observation group was(22.87±3.15)months,longer than(16.42±2.27)months in the control group,the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the control group was 14.29%,which was lower than 35.71%in the observation group,the difference was statistically significant(P<0.05).Conclusion Rituximab combined with high-dose methotrexate can improve the therapeutic effect of primary central nervous system lymphoma,prolong the survival time,and improve the quality of life of patients.But the adverse reactions are obvious,so it should be used as appropriate.