协同干预模式对直肠癌新辅助化疗患者营养状况、癌因性疲乏程度及生活质量的影响

目的探讨协同干预模式对直肠癌新辅助化疗患者营养状况、癌因性疲乏程度及生活质量的影响。方法依据干预方式将150例直肠癌新辅助化疗患者分为观察组和对照组,每组75例,对照组患者化疗过程中给予常规干预,观察组患者化疗过程中给予协同干预模式管理。干预前后,采用主观整体营养评估量表(PGSGA)和血清白蛋白水平评估两组患者的营养状况;采用癌因性疲乏量表评估两组患者的癌因性疲乏程度;采用生活质量量表(QOL)评估两组患者的生活质量。结果干预后,观察组患者PG-SGA评分明显低于本组干预前,两组患者癌因性疲乏量表评分均明显低于本组干预前,血清白蛋白水平和QOL量表各维度评分均明显高于本组干预前,且观察组患者PG-SGA评分、癌因性疲乏量表评分均明显低于对照组患者,血清白蛋白水平和QOL量表各维度评分均明显高于对照组患者,差异均有统计学意义(P﹤0.01)。结论协同干预模式可改善直肠癌新辅助化疗患者的营养状况及癌因性疲乏程度,提高患者化疗期间的生活质量。

Effect of collaborative intervention mode on nutritional status,cancer-related fatigue,and quality of life of patients with rectal cancer receiving neoadjuvant chemotherapy

Objective To investigate the effect of collaborative intervention mode on nutritional status,cancer-related fatigue,and patients’quality of life with rectal cancer receiving neoadjuvant chemotherapy.Method According to the intervention method,150 patients with rectal cancer neoadjuvant chemotherapy were divided into observation group and control group,with 75 cases in each group.Patients in the control group were given routine intervention during chemotherapy,and patients in the observation group were given a collaborative intervention mode management during chemotherapy.Before and after the intervention,the patient-generated subjective global assessment(PG-SGA)and serum albumin levels were tested and used to compare two groups of patients’nutritional status.The cancer-related fatigue scale was used to assess the degree of cancer-related fatigue of the two groups;the quality of life(QOL)scale was used to evaluate the quality of life of the two groups of patients.Result After the intervention,the PG-SGA scores of the observation group were significantly lower than those before the intervention,and the cancer-related fatigue scale scores of the two groups were significantly lower than those before the intervention,the serum albumin level and QOL scale scores were all significantly higher than before the intervention in this group(P<0.01).The PG-SGA scores and cancer-related fatigue scale scores of the observation group were significantly lower than those of the control group,and the serum albumin level and QOL scale scores were significantly higher than those of the control group,the differences were statistically significant(P<0.01).Conclusion The collberative intervention model can effectively improve the nutritional status and cancer-related fatigue of rectal cancer patients undergoing neoadjuvant chemotherapy and improve patients’quality of life during chemotherapy.