Histochemical demonstration of terminal deoxynucleotidyl transferase in leukemia |
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Authors: | Hecht, T Forman, SJ Winkler, US Santos, S Winkler, KJ Carlson, F Maslow, WC Borer, WZ Blume, KG |
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Abstract: | White blood cells from 22 patients with leukemia and lymphoma were studied for the presence of terminal deoxynucleotidyl transferase with a peroxidase-antiperoxidase method. The enzyme was detected in leukemic cells of 5 patients with acute lymphoblastic leukemia and 1 patient with chronic myelogenous leukemia, whereas 16 patients with different forms of leukemia or lymphoma were negative for this enzyme. Comparative studies using a biochemical and an indirect immunofluorescence assay revealed complete concordance between these three methods. |
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