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The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke |
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| Authors: | Brad A Sutherland Ain A Neuhaus Yvonne Couch Joyce S Balami Gabriele C DeLuca Gina Hadley Scarlett L Harris Adam N Grey Alastair M Buchan |
| Affiliation: | 1Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK;2Centre for Evidence Based Medicine, University of Oxford, Oxford, UK;3Norfolk and Norwich University Teaching Hospital NHS Trust, Norwich, UK;4Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK |
| Abstract: | The clinical relevance of the transient intraluminal filament model of middle cerebral artery occlusion (tMCAO) has been questioned due to distinct cerebral blood flow profiles upon reperfusion between tMCAO (abrupt reperfusion) and alteplase treatment (gradual reperfusion), resulting in differing pathophysiologies. Positive results from recent endovascular thrombectomy trials, where the occluding clot is mechanically removed, could revolutionize stroke treatment. The rapid cerebral blood flow restoration in both tMCAO and endovascular thrombectomy provides clinical relevance for this pre-clinical model. Any future clinical trials of neuroprotective agents as adjuncts to endovascular thrombectomy should consider tMCAO as the model of choice to determine pre-clinical efficacy. |
| Keywords: | Ischemic stroke middle cerebral artery occlusion endovascular thrombectomy cerebral blood flow animal models |