The gene for incontinentia pigmenti: failure of linkage studies using DNA probes to confirm cytogenetic localization |
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| Authors: | Ann Harris Shelley Lankester Eric Haan Judith Beres Maj Hulten Judit Szollar Linda Soutter Martin Bobrow |
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| Affiliation: | Paediatric Research Unit, United Medical School of Guy's Hospital, London, UK. |
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| Abstract: | Probes for restriction fragment length polymorphisms mapping between Xp21 and Xq22.3 have been used in a linkage study of incontinentia pigmenti (IP). Six independent sporadic cases of disorders resembling IP with X-autosome translocations involving the same X chromosome breakpoint (Xp11) have been reported. These observations suggest that the IP gene may be located in the Xp11 chromosomal region. However, the linkage study with DNA probes has failed to confirm this localisation. |
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| Keywords: | DNA probes incontinentia pigmenti linkage |
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