Post graft development of short children treated with growth hormone before kidney graft |
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Authors: | D. Simon Myriam Rosilio Anne Maisin Michel Remesy Véronique Baudouin Chantal Loirat Paul Czernichow |
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Affiliation: | (1) Pediatric Endocrinology and Diabetology Unit, Robert Debré Hospital, 48 Boulevard Sérurier, F-15019 Paris, France e-mail: dominique.simon@rdb.ap-hop-paris.fr Tel.: +33-1-40032000 (extension 3386), Fax: +33-1-40032429, FR;(2) Lilly Laboratories, Saint-Cloud, France, FR;(3) Pediatric Nephrology Unit, Robert Debré Hospital, Paris, France, FR;(4) Pediatric Nephrology Unit, Purpan Hospital, Toulouse, France, FR |
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Abstract: | Sixteen prepubertal patients with chronic renal failure (CRF) were given daily recombinant human growth hormone (rhGH) treatment (1.2 IU/kg per week) for 2.6±1.6 years until kidney transplant. Therapy was then discontinued and the patients followed for a further 3.5±1.4 years. During treatment, mean height increased from –3.0±0.9 standard deviation score (SDS) to –1.9±1.4 SDS (P<0.001) at the time of transplantation, corresponding to a mean height gain of +1.2±0.9 SDS. After discontinuation of rhGH therapy, prepubertal children continued a partial catch-up growth with a height gain of +0.5±0.8 SDS for the follow-up period. Conversely, negative changes of height were observed in pubertal transplanted children: –0.5±0.4 SDS in patients grafted at early stages of puberty (P2–P3) and –0.15±0.9 SDS in patients grafted at late stages of puberty (P4–P5). These data confirmed the benefit of rhGH therapy in CRF patients. Nevertheless, only early initiation of rhGH treatment led some of these patients to their target height at transplantation, thus preserving their potential growth. Reinitiation of rhGH therapy after transplantation should be considered in order to complete catch-up growth to target height in prepubertal children. Received: 23 July 1998 / Revised: 8 December 1998 / Accepted: 13 December 1998 |
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Keywords: | Chronic renal failure Renal transplantation Growth Puberty Recombinant human growth hormone therapy Steroid therapy Final height |
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