Behaviour of urinary 2,5-hexanedione in occupational co-exposure to n-hexane and acetone |
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Authors: | Antonio Cardona Dolores Marhuenda M. José Prieto Juan Martí J. Francisco Periago J. Manuel Sánchez |
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Affiliation: | (1) Department of Toxicology and Legal Medicine, Alicante University, Faculty of Medicine, Aptdo 374, E-03080 Alicante, Spain;(2) National Institute of Occupational Safety and Hygiene, Aptdo 35, E-30120 El Palmar, Murcia, Spain;(3) Occupational Safety and Hygiene Service of Alicante, Generalidad Valenciana, c/ Hondón de los Frailes 1, E-0305 Alicante, Spain |
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Abstract: | We analysed the relationship between free 2,5-hexanedione (2,5-HD) and total 2,5-HD in the urine of 87 workers exposed to n-hexane and other solvents (hexane isomers, acetone and toluene), in relation to different working conditions. The concentration of free 2,5-HD in urine of workers exposed to n-hexane was about 12% of total urinary 2,5-HD. The most significant correlation (r = 0.936) was that of total 2,5-HD in urine with environmental n-hexane and exhaled air. With equal exposure to n-hexane, the concentrations in urine of free and total 2,5-HD increased when cutaneous absorption was involved (gloves not used), during the working week and with co-exposure to acetone. An analysis of the relationship between combined exposure to acetone and urinary concentrations of the various forms of 2,5-HD suggests that acetone might influence the toxicokinetics of n-hexane, increasing the proportion of free 2,5-HD. |
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Keywords: | Biological monitoring n-Hexane 2,5-Hexanedione Acetone Co-exposure |
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