地高辛间歇维持量治疗窦性心律心力衰竭

目的 探讨间歇应用维持量地高辛治疗窦性心律心力衰竭的临床疗效与安全性。方法115例窦性心律心力衰竭患者随机分为2组;A组58例,采用间歇维持量地高辛治疗;B组57例,采用持续维持量地高辛治疗。结果 2组患者治疗前与治疗后3个月、6个月比较心率(HR,次/min),A组分别为97±14、76±15、75±13,B组分别为101±11、76±13、76±15;左心室射血分数(LVEF)A组分别为0.37±0.13、0.42±0.12、0.45±0.13,B组分别为0.37±0.14、0.42±0.11、0.44±0.14。2组治疗后与治疗前HB与LVEF比较差异均有非常显著性(P<0.01),2组间治疗前后比较差异无显著性(P>0.05),但地高辛过量和中毒的发生率2组间差异有非常显著性(P<0.01)。结论 间歇维持量地高辛疗法与持续维持量疗效相似,但可降低洋地黄过量或中毒发生率,是一种安全有效的临床投药方法。

Intermittent maintenance dose digoxin treating patients with congestive heart failure in sinus rhythm

Objective To explore the curative effects and safety of intermittent maintenance dose digoxin treating patient with congestive heart failure in sinus rhythm. Methods 115 cases of congestive heart failure with sinus rhythm were randomly divided into A group and B group. A group(58 cases) was treated by intermittent maintenance dose digoxin. B group (57 cases) was treated by continuous maintenance dose digoxin. All patients were observed for 6 months.Results A group was compared with B group for the left ventricular ejection fraction(LVEF) and heart rate (HR) before treatment and 3 th, 6th month after treatment.LVEF was respectively 0.37 ±0.13,0.42 ±0.12,0.45 ±0.13 in A group and 0.37 ±0.14,0.42±0.11,0.44 ±0.14 in B group; HR was 97 ±14,76±15,75±13 in A group and 101 ±11,76±13,76±15 in B group.There were difference significantly between before treatment and after treatment in two groups ( P < 0.01) . No significant difference was found between A group and B group for before treatment and after treatment( P > 0.05) . But, significant differences were found for digoxin overload or toxication in group A lower than those in group B(3.5% vs 12.3% , P < 0.01).Conclusion The results show intermittent maintenance dose digoxin therapy may be effective and safe for patients with congestive heart failure in sinus rhythm.