子宫动脉栓塞术治疗子宫肌瘤临床研究

目的　研究平阳霉素碘化油乳剂经子宫动脉栓塞治疗子宫肌瘤的疗效、安全性和不良反应。方法　对 15 8例子宫肌瘤患者进行超选择性子宫动脉栓塞治疗 ,所用材料为平阳霉素碘化油乳剂及明胶海绵颗粒。术后随访 3～ 18个月 ,观察栓塞术后子宫大小与肌瘤体积的变化及不良反应。结果　 15 0例行双侧子宫动脉栓塞 ,8例完成单侧栓塞。术中造影显示子宫动脉明显增粗 ,肌瘤滋养血管呈螺旋状 ,肌瘤染色明显 ,排空延迟。 6例术后 1周行子宫切除术 ,手术标本病理观察肌瘤呈点片状坏死 ,小出血点。随访 3个月 ,症状缓解率达 90 .5 %。其中子宫出血症状完全消失者占 89.4 % ,盆腔胀痛及腹胀等压迫症状消失占 91.3% ,肌瘤体积平均缩小 80 % ,子宫体缩小 4 8%。结论　早期结果表明 ,平阳霉素碘油乳剂子宫动脉栓塞治疗子宫肌瘤疗法安全有效 ,并发症发生率低 ,是子宫肌瘤的较好治疗方法

Clinical study on hysteromyoma treated with uterine artery embolization

Objective To study the therapeutic effect, side-effect and safety of uterine artery embolization of hysteromyoma with pinyangmycin and lipiodol emulsion. Methods Embolization carried out selectively through uterine artery with pinyangmycin and lipiodol emulsion of 158 hysteromyoma was followed up for 3-18 months with observation of the size of hysteromyoma, the change of corpus uteri and the degree of reactions. Results All cases were embolized successfully including 150 cases of bilateral and 8 cases of unilateral uterine arterial embolization. The appearance of uterine arteries showed obvious arterial enlargement with spiral hypervasculature, tumor staining and prolonged opacification. Six patients underwent hysteroectomy 1 week after the embolization. The specimens demonstrated flaky necrosis with small bloody specks under pathologic examination. The alleviation rate of symptoms were 90.5% with recovery of normal menstrual cycle as 89.4%. The compressive symptoms of hypogastric pain and abdominal distention disasppeared in 91.3%. The reduction in size of hysteromyoma and corpus utei were 80% and 48% on average respectively. Conclusion The primary results demonstrates that uterine artery embolization of hysteromyoma is safe and effective, with low complication rate and more advantage over surgical approach.