胃癌中幽门螺杆菌感染与原癌基因c—met表达及预后研究

目的　研究幽门螺杆菌(Hp)感染的胃癌(GC)组织中c-met表达及(Hp)感染对胃癌预后的影响。方法　经病理证实，不同病变胃粘膜145例以免疫组化检测c-met基因表达，以W-S法及快速尿素酶试验检测(Hp)感染。结果　在浅表性胃炎(CSG)、萎缩肠化生胃炎(CAG+IM)、异型增生(DYS)、早期GC和进展期GC中，c-met基因表达率分别为25.53%，51.28%，61.54%，66.67%和68.42%，CAG+IM、DYS、GC均显著高于CSG(P＜0.05)。肠型胃癌c-met阳性表达与(Hp)感染密切相关。CAG+IM，DYS和GC组c-met阳性表达(Hp)感染者明显高于阴性组。(Hp)阳性者5年生存期显著短于(Hp)阴性者。结论　(Hp)感染和c-met表达与胃粘膜增殖和恶化有关，前者也与胃癌预后有关。

THE PROGNOSTIC RESEARCH AND RELATIONSHIP BETWEEN HELICOBACTER PYLORI AND EXPRESSION OF C-MET ONCOGENE IN GASTRIC CARCINOMAS

Aim To determine whether there is a relationship between Helicobacter pylori(Hp) and expression of c met oncogene in gastric mucosal lesions,and prognostic significance of gastric carcinomas(GC).Methods Hp and expression of c met were investigated in 145 gastric mucosal lesions by using immunohistochemistry,and Hp was examined by Warthin starry method.Results For chronic superficial gastritis (CSG),chronic atrophic gastritis and intestinal mataplasia (CAG IM),dysplasia(DYS),early GC and advanced GC,the expression rates of c met were 25.53%,51.28%,61.54%,66.67% and 68.42% The positive rates were higher in CAG IM,DYS and GC than in CSG(P<0.05).Expressions of c met of Hp positive were higher than Hp negative in intestinal GC(P<0.05).Expressions of c met were correlated significantly with Hp positive in CAG IM,DYS and GC.The survival rate of patients with Hp non infection.Conclusions Hp infection and expression of c met may be associated with in proliferation and malignant transformation of gastric mucosa.Hp infection is associated with prognosis of gastric carcinoma.