Dietary effects on the pharmacokinetics of three carcinogenic nitrosamines. |
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| Authors: | J S Wishnok A E Rogers O Sanchez M C Archer |
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| Affiliation: | 1. Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 USA |
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| Abstract: | The concentrations of N-nitrosodimethylamine (DMN), N-nitrosodiethylamine (DEN), and N-nitrosodibutylamine (DBN) were monitored as a function of time in the blood and liver of rats fed either a normal diet or a diet marginally deficient in lipotropes. The disappearance of each nitrosamine from the blood showed first-order kinetics. Hepatic clearance of DEN and DBN also followed first-order kinetics, but the time dependence of DMN concentration in liver tissue showed an anomalous behavior. Diet-related differences in the pharmacokinetic data did not explain the variations in carcinogenicity caused by diet. |
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| Keywords: | To whom correspondence should be addressed. |
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