T-cell-mediated pure red-cell aplasia in systemic lupus erythematosus: response to cyclosporin A and mycophenolate mofetil |
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| Authors: | Arcasoy Murat O Chao Nelson J |
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| Affiliation: | Department of Hematogenetics, Institute of Immunohaematology, Indian Council of Medical Research, Mumbai, India. |
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| Abstract: | We report on three novel polymorphisms in and around the beta globin gene. Two of them are intronic (IVS2) polymorphisms (IVS 2 nt 200-203 (-CTTT) and IVS2 82-83 (-AG)). The third is a novel G-->C substitution at nt +1707 related to the beta globin cap site. This +1707 G-->C polymorphism was detected in 23.5% of chromosomes among 140 samples from India. It seems to be a novel but common polymorphism among Indians. There was no linkage between these novel polymorphisms and any beta thalassemia mutation. |
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| Keywords: | β globin gene novel polymorphisms |
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