急性脑梗塞病人白细胞变形能力变化及临床意义

本文观察了急性脑梗塞（ＡＣＩ）病人白细胞变形能力（ＬＤ）的变化，同时检测了血浆总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、纤维蛋白原（Ｆｉｇ）、脂质过氧化物代谢产物丙二醛（ＭＤＡ）和血浆镁离子的浓度变化。结果显示，ＡＣＩ病人ＬＤ较对照组明显降低，差异有显著性意义（Ｐ＜０．００１），且ＬＤ随着血浆ＴＣ、ＴＧ、Ｆｉｇ、ＭＤＡ浓度增高和血镁浓度降低而进一步降低。本结果提示，在预防和治疗ＡＣＩ过程中，提高ＬＤ，改善微循环，对增加缺血脑组织的血液灌流，缩小梗塞面积和改善预后具有重要的临床意义。

The Changing of Leukocyte Deformability in Patients With Acute Cerebral Infarction and its Clinical Significance

The leukocyte deformability (LD) was observed in patients with acute cerebral infarction (ACI), and the concentration of total cholesterol (TC), triglyceride (TG), malondialdehyde (MDA),fibrinogen (Fig) and magnesium were measured also. The results showed that LD of patients decreased significantly as compared with that of normal controls (P<0. 001),and LD of patients reduced further with rise in level of TC,TG,Fig,MAD and reduction of plasma magnesium concentration. These results indicated that enhancing the LD and improving microcirculation, in the process of prevention and treatment of ACI may have high value in increasing the blood flow of capillaries in ischemic cerebrum,reducing the area of infarction and improving the prognosis of patients;