肺癌患者化疗前后SIL-2R和TNF检测的临床意义

目的 :探讨了 4 0例肺癌患者化疗前后血清中SIL - 2R和TNF含量的变化。方法 :应用放免法和酶免法检测 4 0例肺癌患者血清中SIL - 2R和TNF含量并与 35名正常人作比较。结果 :肺癌患者在化疗前血清中SIL - 2R和TNF含量显著地高于正常人组 (p <0 0 1 ) ,化疗后明显下降 (p <0 0 5 )。 结论 :血清中SIL- 2R和TNF水平可作为肺癌患者免疫功能监测指标之一 ,并可作为疗效判断参考

Clinical Significance of Determination of SIL-2R and TNF Levels in Patients with Lung Carcinoma Undergoing Chemotherapy

Objective To detect the changes of serum SIL-2R and TNF levels in 40 patients with lung cancer undergoing chemotherapy. Methods Serum TNF levels were determined with RIA and SIL-2R levels with EIA in 40 lung cancer patients both before and after chemotherapy as well as in 35 controls. Results Before chemotherapy, serum TNF and SIL-2R levels in the patients were significantly higher than those in the controls ( p <0 01, p <0 001). After chemotherapy, the levels were much lowered but still higher than those in the controls ( p<0 05, p <0 05). Conclusion Serum levels of SIL-2R and TNF might be useful for monitoring immune function in patients with lung carcinoma as well as for predicting therapeutic outcomes.