| 氧氟沙星片的药物动力学和生物利用度 |
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| 引用本文： | 仇益群,杜永红,黄仲义. 氧氟沙星片的药物动力学和生物利用度[J]. 中国新药与临床杂志, 1994, 0(4) |
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| 作者姓名： | 仇益群 杜永红 黄仲义 |
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| 作者单位： | 上海静安区中心医院临床药理室 |
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| 摘 要： | 在８例健康志愿者中进行国产与进口氧氟沙星片药物动力学和生物利用度研究。随机交叉试验设计单剂量口服４００ｍｇ，用ＨＰＬＣ测定血药浓度，按非室模型计算，求得２种制剂各项药物动力学参数，无显著性差异（Ｐ＞０．０５），以进口药片为标准（Ｆ＝１）求得国产药片的相对生物利用度为９２．２％。
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| 关 键 词： | 氧氟沙星；片剂；药物动力学；生物学效用 |
Pharmacokinetics and bioavailability of ofloxacin tablets |
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| CHOU Yi-Qun,DU Yong-Hong,HUANG Zhong-Yi. Pharmacokinetics and bioavailability of ofloxacin tablets[J]. Chinese Journal of New Drugs and Clinical Remedies, 1994, 0(4) |
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| Authors: | CHOU Yi-Qun DU Yong-Hong HUANG Zhong-Yi |
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| Abstract: | A single dose of tablet Tarivid (Daiichi Pharmaceutical Co Ltd,Japan)and ofloxacin(Li Zhu Pharmaceutical Factory,Zhuhai,China)of 400 mg ofloxacin was given to 8 Chinese healthy volunteers in an open,randomized cross-over study.Drug concentrations in serum were assayed by HPLC method.The serum time-concentrations after medication conformed to non-compartment model.Pharmacokinetic parameters after the 2 tablets did not differ significantly.The bioavailability of domestic ofloxacin tablets was 92.2% of that of tablet Tarivid. |
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| Keywords: | ofloxacin tablet pharmacokinetics biological availability |
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