HLA-DQB1*0304-DRB1*0408 haplotype associated with insulin–dependent diabetes mellitus in populations in the eastern Baltic region |
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| Authors: | J. Ilonen,S. Koskinen,S. Nejentsev,M. Sjö roos,M. Knip,E. I. Schwartz,B. Adojaan,L. Kovalchuk,A. Sochnevs |
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| Affiliation: | Turku Immunology Centre and Departments of Virology;Biotechnology, University of Turku, Finland;Department of Medical Genetics, Paediatric Medical Institute, St. Petersburg, Russian Federation;Department of Paediatrics, University of Oulu, Finland;Department at Endocrinology, Tartu University Hospital, Estonia;Institute of Immunology, Medical Academy of Latvia, Riga, Latvia |
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| Abstract: | The rare HLA-DQB1*0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P=0.0001). HLA-DQB1*0304 in these populations was associated with DRB1*0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ β-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility. |
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| Keywords: | insulin-dependent diabetes mellitus HLA-DR4 haplotype HLA-DQB1*0304 |
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