水飞蓟宾磷脂复合物对慢性乙型肝炎患者血清细胞因子及肝纤维化指标的影响

目的观察水飞蓟宾磷脂复合物对慢性乙型肝炎患者肝纤维化指标及细胞因子的影响。方法83例慢性乙型肝炎患者按就诊顺序随机分为对照组（n=42）和观察组（n=41），对照组采用常规保肝和支持治疗，观察组在对照组基础上加用水飞蓟宾磷脂复合物105mg/次，3次／d，治疗前后检测肝功能，用酶联免疫吸附法检测血清转化生长因子β（TGF-β）、肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6），应用放射免疫法检测血清纤维化指标透明质酸（HA）、Ⅲ型前胶原（PCⅢ）、层粘连蛋白（LN）、Ⅳ型胶原（CⅣ）。结果观察组治疗后血清TGF—β（174．4±49．7）μg/L、TNF—α（89．5±25．8）μg/L、IL-6（232．6±61．7）μg/L及HA（180±54）μg/L、PCⅢ（171±49）μg/L、LN（168±39）μg/L、C1V（153±37）μg/L水平较治疗前及对照组治疗后均显著降低（P〈0．05）。结论水飞蓟宾磷脂复合物通过影响慢性乙型肝炎患者血清细胞因子等发挥抗肝纤维化作用。

Influence of Silybin capsules on fibrosis indexes and cytokines in patients with hepatitis B

Objective To observe the influence of silybin capsules (SC) on hepatic fibrosis indexes and cytokines in patients with chronic hepatitis B(CHB). Methods Eighty-three patients with chronic hepatitis B were randomly divided into control group(n =42) and observation group(n = 41) acording to visiting order. The control group received general protective and supportive treatment with polarized solution, energy misture, potassium mag-nessium aspartape, hypoxanthine riboside, salvia miltiorrhiza and so on. Patients in observation group were added SC 105mg, three times per day. Serum precollagen type Ⅲ( PC Ⅲ), Ⅳ-typo collagen (CⅣ), hyaluronate (HA), laminin (LN) and transforming growth factor-beta (TGF-β), tumor necrosis factor alapha(TNF-α), interleukin 6 (IL-6) levels were measured by specific-RIA and ELISA methods before and after the treatment. Results After treatment, serum TGF-β(174.4±49.7) μg/L], TNF-α(89.5±25.8) μg/L], IL-6 (232.6±61.7) μg/L], HA (180.24±53.78) μg/L], PC Ⅲ(171.33±48.65) μg/L], LN ( 168.06±38.57) μg/L] and CⅣ (153.46±36.52) μg/L] levels in observation group were obviously decreased than those in control group. Conclusion Silybin capsules influences the levels of cytokines in patients with CHB and has anti-fibrosis effect on liver tissue.