Somatosensory evoked response source localization using actual cortical surface as the spatial constraint |
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| Authors: | M Akhtari HBA D McNay M Mandelkern B Teeter H E Cline J Mallick G Clark R Tatar R Lufkin K Chan R L Rogers W W Sutherling |
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| Institution: | (1) Neuromagnetism Laboratory, Hospital of the Good Samaritan, 627 South Lucas St., Suite 610, 90017 Los Angeles, CA, USA;(2) Department of Physics, UC Irvine, Irvine, CA, USA;(3) General Electric Medical Systems, USA;(4) Dept. of Dentistry, UCLA School of Medicine, Los Angeles, CA, USA;(5) Dept. of Radiology, UCLA School of Medicine, Los Angeles, CA, USA;(6) Dept. of Neurology, UCLA School of Medicine, Los Angeles, CA, USA |
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| Abstract: | Summary We localized right median nerve somatosensory evoked responses in a normal human subject using an equivalent dipole method applied to magnetic field recordings. High resolution, 3-dimensional MRI data were used to confine source locations to the cortical surface. Results localized in Brodmann area 3b corresponding to location of hand somatosensory cortex derived from direct brain stimulation studies. The solution was unique and total computational time for an exhaustive, brute-force search was small and the results realistic due to applied anatomical constraints. This study demonstrates feasibility of accurate, non-invasive, realistic localization of dynamic human cortical function using spatial constraints provided by MRI images. |
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| Keywords: | Magnetoencephalography Localization MRI |
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