围生期HBV高危人群防治乙肝依从性及新生儿HBV感染状况

【目的】了解围生期HBV高危人群防治乙型肝炎依从状况与新生儿HBV感染及其影响因素。【方法】选取2008年1月-2009年1月，在河北北方学院附属第一医院妇产科例行常规产前检查的血清学HBsAg和／或HBV—DNA阳性而肝功能正常的孕妇及其配偶173例，进行防治乙肝健康教育，于新生儿出生时采集脐静脉血检测HBV—DNA，对其就乙肝防治依从状况进行问卷调查，并复查新生儿父母的HBV5项血清学。【结果】44．5％调查者防治乙肝依从状况属中等；不同的人口学特征围生期HBV高危人群对乙肝防治差异有统计学意义，其中女性、受教育程度高、市区的依从性好（P〈0．05）；防治乙肝依从性好者其新生儿HBV感染率低于依从性差者，但差异无统计学意义（P〉0．05）；夫妇双方为HBV阳性的其新生儿HBV感染率高于单方阳性的，差异有统计学意义（P〈0．01）。【结论】加强乙肝健康教育宣传，应在产前、孕前、甚至婚前常规筛查HBV，及时发现HBsAg携带者，并建议其在体内HBV—DNA负荷量低水平时孕育下一代。

Compliance about prevention and treatment of hepatitis b among hbv high risk population of perinatal period in zhangjiakou

Objective] To investigate the current compliance about prevention and treatment of hepatitis B among HBV high risk population of perinatal period in Zhangjiakou and its influence factors,neonatal HBV infection. Methods A questionnaire survey of compliance about prevention and treatment of hepatitis B among 173 HBV high risk cases during perinatal period,admitted to Hebei North University First Hospital from .January 2008 to January 2009,was conducted after delivery.These cases were HBV carrier pregnant women and their spouses,who study health education about hepatitis B during pregnant period.The serum HBV was determined in neonatal cord blood during delivery and their parents after delivery,respectively.Result Of the investigated cases,44.5% had the average compliance. There was statistically difference in compliance degree about prevention and treatment of hepatitis B among HBV high risk pregnant women and their spouses with different demographic characteristics; Such as female,high education degree, Living urban area had good compliance （P〈0.05）.Neonatal HBV infection rate of 51 good compliance cases was lower than of 45 poor compliance cases,no significant difference was confirmed in different degree compliance（P〉0.05）.The positive rate of umbilical blood HBV-DNA for newborns,whose parents were both HBV positive,was higher than whose father or mother singular HBV positive （P〈0.01）.Conclusion Great efforts should be made to popularize the knowledge about hepatitis B.Testing HBV should be carried out among population before delivery,pregnancy,and and marriage;so as to discover in time HBV carrier and suggest to produce young when lower HBV-DNA level of their body.