Needle-free skin patch vaccination method for anthrax |
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| Authors: | Matyas Gary R Friedlander Arthur M Glenn Gregory M Little Stephen Yu Jianmei Alving Carl R |
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| Affiliation: | Department of Membrane Biochemistry, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA. gary.matyas@na.amed.army.mil |
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| Abstract: | Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI) induced long-term neutralizing antibody titers that were superior to those obtained with aluminum-adsorbed rPA. In addition, rPA alone exhibited adjuvant activity for TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal anthrax challenge. |
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