复方大黄片对脓毒症患者血浆 D-乳酸及前降钙素表达的影响

目的：研究复方大黄片对脓毒症患者血浆D-乳酸及前降钙素表达的影响。方法：2013年2月-2014年2月入住我院外科的脓毒症患者55例，分为大黄治疗组（30例）和非大黄治疗组（25例）。大黄治疗组给予复方大黄片3g/次，1次/8h服用，附带常规治疗，常规治疗包括抗生素、舒普深、特治星、泰能；保证水和电解质以及营养的正常供给。非大黄治疗组只给予常规治疗。两组病例治疗前和治疗后1d、4d测定血浆D-乳酸和前降钙素水平变化情况。结果：治疗前大黄治疗组患者的血浆D-乳酸水平和前降钙素水平与非大黄治疗组比较，差异无显著性（ P＞0．05）；治疗1d、4d后血浆D-乳酸水平大黄治疗组明显低于非大黄治疗组（P＜0．05）。治疗1d后两组血浆前降钙素水平无明显差异（ P＞0.05）。治疗4d后两组病例的血浆前降钙素水平比较结果中，大黄治疗组明显低于非大黄治疗组，差异存在显著性（P＜0．01）。结论：复方大黄片能改善脓毒症患者的肠道通透性，减少细菌易位。

Effects of Compound Rhubarb Pill on Plasma D-lactate and Procalctionin Expressions in Patients with Sepsis

Objective：To study the compound big porn plasma D-lactic acid in patients with sepsis and the former ex-press the effect of calcitonin .Methods：February 2013 to February 2014 ,our hospital surgical of 55 patients with sep-sis ,rhubarb treatment group （30 cases） and non rhubarb treatment group （25 cases） .Rhubarb treatment group given compound rhubarb ,3g/second ,1/8h ,with routine therapy and routine therapy including antibiotics ,shope deep ,Sin-gapore and Thailand can cure;assure the normal supply of water and electrolyte ,and nutrition .The rhubarb treatment group given conventional treatment .Two groups of cases before and after treatment 1d ,4d to determine patients plasma D-lactic acid and calcitonin level changes .Results：The treatment group before treatment the patient’s level of plasma D-lactic acid and calcitonin level before ,with the rhubarb treatment group ,there was no significant difference （P〉0.05） , 1d ,4d after treatment plasma D-lactic acid levels rhubarb treatment group was lower than that of rhubarb treatment group （P〈0 .05） .Treatment 1 day after plasma calcitonin level before the two groups no significant difference （P〉0.05） .4 days after treatment of two groups of cases before the plasma calcitonin level comparison results of rhubarb treatment group significantly below the rhubarb treatment group as a result ,there is significant difference （P〈0.01） . Conclusion：The compound rhubarb could improve intestinal permeability in patients with sepsis ,reduce bacteria trans-location .