| T细胞受体基因转导的研究和应用 |
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| 引用本文： | 李闯,李扬秋.T细胞受体基因转导的研究和应用[J].国际免疫学杂志,2007,30(3):139-143. |
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| 作者姓名： | 李闯 李扬秋 |
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| 作者单位： | 510632,广州,暨南大学医学院血液病研究所;510632,广州,暨南大学医学院血液病研究所 |
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| 基金项目： | 广东省自然科学基金重点项目（05103293） |
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| 摘 要： | T细胞受体（TCR）作为T细胞识别抗原的分子，在免疫应答和免疫调节中发挥重要的作用。利用转基因技术，将识别特定抗原的TCR基因转导到正常T细胞中，使其强制性表达了识别特异抗原TCR，从而达到发挥特异性免疫效应的目的，为产生有效的特异性免疫治疗开辟了一条新途径。
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| 关 键 词： | T细胞受体 免疫治疗 基因转导 |
| 修稿时间： | 2006-06-25 |
The application and research of TCR gene transduction |
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| Li Chuang.The application and research of TCR gene transduction[J].International Journal of Immunology,2007,30(3):139-143. |
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| Authors: | Li Chuang |
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| Institution: | Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, China |
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| Abstract: | As the molecule of recognizing the specific antigen of T lymphocyte, T cell receptor (TCR) plays an important role in the immunity response and immunity regulation. Utilizing the technology of gene transfer, the specific TCR gene was transferred into the normal T lymphocyte.T lymphocyte was forced to express the specific TCR, and then can exercise the specific immunological effect. It provides a new strategy to the specific immunotherapy. |
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| Keywords: | TCR Immunotherapy Gene transduction |
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