| Releasing of Cupric Ion of Three types of Copper-bearing Intrauterine Contraceptive Device in Simulated Uterine Fluid |
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| 引用本文： | Jie GAO1,Ying LI2,Jian-ping LIU1,Xuan GU1 1.Pharmaceutic Institute of China Pharmaceutical University,Nanjing 210009,China 2.Institute of Planned Parenthood Research of Jiangsu Province,Nanjing 210036,China. Releasing of Cupric Ion of Three types of Copper-bearing Intrauterine Contraceptive Device in Simulated Uterine Fluid[J]. 生殖与避孕(英文版), 2007, 18(1): 33-39. DOI: 10.1016/S1001-7844(07)60005-4 |
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| 作者姓名： | Jie GAO1 Ying LI2 Jian-ping LIU1 Xuan GU1 1.Pharmaceutic Institute of China Pharmaceutical University Nanjing 210009 China 2.Institute of Planned Parenthood Research of Jiangsu Province Nanjing 210036 China |
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| 作者单位： | Jie GAO1，Ying LI2，Jian-ping LIU1，Xuan GU1 1.Pharmaceutic Institute of China Pharmaceutical University，Nanjing 210009，China 2.Institute of Planned Parenthood Research of Jiangsu Province，Nanjing 210036，China |
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| 摘 要： | Objective To compare the cupric ion releasing in vitro of the three IUDs.Methods The stability of cupric ion releasing of IUDs including TCu 380A IUD (TCu 380A), Multiload Cu375 IUD (MCu 375) and Yuangong 365 copper-bearing indomethacin-releasing IUD (Yuangong 365) by the determination of cupric ion releasing in simulated uterine fluid. The simulated uterine fluid was used for releasing media. Copper ion was determined by flame atomic absorption spectrometerResults The cupric ion releasing of three IUDs were instable at the beginning and tend to be stable gradually. In the stable phase, the average level of cupric ion releasing of TCu380A, MCu375 and Yuangong 365 were 4.25±2.71 -7.62±6.42 μg,4.92±1.23 -8.62±3.08 μg and 2.19±0.40-4.68±1.66 μg, respectively. TCu380A had higher instable releasing level than those of Yuangong 365 (P＜0. 05).Conclusion TCu 380A and MCu 375 showed a "burst release" during the first few days and the former was of great significance(P＜0. 05). The initial cupric ion releasing of Yuangong 365 appeared to be the lowest, followed by MCu375 and TCu380A in a releasing order.
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| 关 键 词： | 模拟子宫流体 含铜宫内节育器 类型 二价铜离子释放 |
| 收稿时间： | 2006-05-23 |
Releasing of Cupric Ion of Three types of Copper-bearing Intrauterine Contraceptive Device in Simulated Uterine Fluid |
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| Jie GAO,Ying LI,Jian-ping LIU,Xuan GU. Releasing of Cupric Ion of Three types of Copper-bearing Intrauterine Contraceptive Device in Simulated Uterine Fluid[J]. Journal of Reproduction and Contraception, 2007, 18(1): 33-39. DOI: 10.1016/S1001-7844(07)60005-4 |
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| Authors: | Jie GAO Ying LI Jian-ping LIU Xuan GU |
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| Affiliation: | 1. TCART Fertility Partners, Division of Reproductive Sciences, Department of Obstetrics and Gynecology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto M5S 2X9, Canada;2. Fertility Ontario, London N6C 5Z2, Canada |
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| Abstract: | Objective To compare the cupric ion releasing in vitro of the three IUDs.Methods The stability of cupric ion releasing of IUDs including TCu 380A IUD (TCu 380A), Multiload Cu375 IUD (MCu 375) and Yuangong 365 copper-bearing indomethacin-releasing IUD (Yuangong 365) by the determination of cupric ion releasing in simulated uterine fluid. The simulated uterine fluid was used for releasing media. Copper ion was determined by flame atomic absorption spectrometerResults The cupric ion releasing of three IUDs were instable at the beginning and tend to be stable gradually. In the stable phase, the average level of cupric ion releasing of TCu380A, MCu375 and Yuangong 365 were 4.25±2.71 -7.62±6.42 μg,4.92±1.23 -8.62±3.08 μg and 2.19±0.40-4.68±1.66 μg, respectively. TCu380A had higher instable releasing level than those of Yuangong 365 (P＜0. 05).Conclusion TCu 380A and MCu 375 showed a "burst release" during the first few days and the former was of great significance(P＜0. 05). The initial cupric ion releasing of Yuangong 365 appeared to be the lowest, followed by MCu375 and TCu380A in a releasing order. |
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| Keywords: | copper-bearing intrauterine contraceptive device Cu-IUD the releasing of cupric ion simulated uterine fluid flame atomic absorption spectrometer |
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