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Effect of malotilate on paracetamol-induced hepatotoxicity |
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| Authors: | M Younes C P Siegers |
| Affiliation: | Institut für Toxikologie der Medizinischen Hochschule Lübeck, Ratzeburger Allee 160, D-2400 Lübeck F.R.G. |
| Abstract: | Malotilate (diisopropyl-1,3-dithiol-2-ylidenemalonate) prevented liver damage induced by paracetamol in male mice only when given 1 h prior to the hepatotoxic agent. Furthermore, it partially inhibited paracetamol-induced glutathione depletion in mouse liver, indicating that the antihepatotoxic activity of malotilate is related to an interaction with the bioactivation of paracetamol. |
| Keywords: | Glutathione hepatotoxicity malotilate paracetamol GPT glutamate-pyruvate transaminase MfO mixed-function oxidase SDH sorbitol dehydrogenase |
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