Eudistomins W and X,two new beta-carbolines from the micronesian tunicate Eudistoma sp |
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Authors: | Schupp Peter Poehner Timo Edrada RuAngelie Ebel Rainer Berg Albrecht Wray Victor Proksch Peter |
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Affiliation: | Institut für Pharmazeutische Biologie, Heinrich-Heine-Universit?t Düsseldorf, Universit?tsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany. |
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Abstract: | Chemical investigation of the Micronesian ascidian Eudistoma sp. afforded two new eudistomin congeners, which were designated eudistomins W (1) and X (2). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic ((1)H, (13)C, COSY, (1)H detected direct, and long-range (13)C-(1)H correlations) and mass spectrometric (EI and ESIMS) data. Compound 2 exhibited antibiotic activity toward Bacillus subtilis, Staphyloccocus aureus, and Escherichia coli and was also found to be fungicidal against Candida albicans in an agar diffusion assay. Compound 1 was selectively active against C. albicans but showed no antibacterial activity. |
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