超声评价高血压大鼠左室肥厚时缬沙坦对其结构和功能的影响

目的：应用高频超声心动图观察肾性高血压大鼠左室肥厚（LVH）时结构和功能的改变。并结合心肌癌肌基因C－FOS，C－MYC表达水平，评价缬沙坦（Valsartan,VAL)对左室构型的影响及可能机制。方法：36只SD大鼠随机分成手术组26只和假手术组10只，手术组鼠制成二肾一类（2K1C）型肾高血压动物模型后，分为高血压组和VAL组各13只。对三组鼠行经胸超声心动图监测并测定心肌C－FOS，C－MYC表达水平。结果：VAL组室壁厚度、心功能及癌基因表达水平与假手术组无显著性差异；与高血压组有显著性差异。结论：超声能准确评价VAL抑制心肌肥厚和保护心功能的作用，后者可是抑制癌基因表达的结果。

Effects of Valsartan onLeft Ventricular Structure and Function in 2K1C Hypertensive Rats Evaluated withEchocardiography

Objective:To observe the hypertrophic left ventricular structure and function by echocardiography in 2K1C renovascular hypertensive rats and to connect with the level of expression of cardiac cellular oncogenes C FOS and C MYC as well as to evaluate the effects of Valsartan(VAL) on LV and its probable mechanism.Methods:36 SD rats were divided randomly into the sham team ( n =10) and the operating team ( n =26). The latter were made into 2K1C renovascular hypertensive rat models and then subdivided into hypertension team ( n =13) and VAL team ( n =13). Three teams who were all studied by echocardiography and expressions of oncogenes C FOS and C MYC were detected by immunohistochemical technique.Results:The changes of rat heart structure and function could be revealed clearly by echocardiography. LV mass correlated well with the real mass. There was no statistical significance between VAL team and the sham in ventricular thickness, heart function and expression of C FOS and C MYC, while there was significant difference between VAL team and hypertension team.Conclusions:Echocardiography can be used to accurately evaluate the effects of VAL on inhibiting LVH and protecting heart function, which perhaps result from inhibiting the expression of oncogenes C FOS and C MYC.