| 醋酸棉酚对大鼠肾皮质形态结构的影响 |
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| 引用本文： | 余铭清,胡艳群,刘子龙,张翠群,吴熙瑞,周厚伦,罗惠先,刘云华.醋酸棉酚对大鼠肾皮质形态结构的影响[J].华中科技大学学报(医学版),1987(2). |
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| 作者姓名： | 余铭清 胡艳群 刘子龙 张翠群 吴熙瑞 周厚伦 罗惠先 刘云华 |
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| 作者单位： | 同济医科大学计划生育研究所
(余铭清，胡艳群，刘子龙，张翠群，吴熙瑞)，同济医科大学基础医学部解剖学教研室
(周厚伦，罗惠先)，同济医科大学基础医学部解剖学教研室(刘云华) |
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| 摘 要： | 醋酸棉酚每天30mg/kg(6次/周)给药6～8周后,大鼠肾曲小管线粒体肿胀,嵴模糊,伴有早期溶酶体增多、增大,形态多样,其后转而减少、变小。肾近曲小管微绒毛水肿,部分肾曲小管基底膜水肿。未见肾小球毛细血管内皮细胞、基膜和足细胞的超微结构明显变化。
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| 关 键 词： | 醋酸棉酚 肾近曲小管 肾远曲小管 肾小球 内皮细胞 |
Morphological Studies of the Influence of Gossypol Acetic Acid on the Renal Cortex of Rats |
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| Yu Mingqing,Hu Yanqun,Liu Zilong,Zhang Cuiqun,Wu Xirui Family Planning Research Institute,Tongji Medical University,WuhanZhou Houlum,Lao Huixian,Liu Yunhua.Morphological Studies of the Influence of Gossypol Acetic Acid on the Renal Cortex of Rats[J].Journal of Huazhong University of Science and Technology(Health Sciences),1987(2). |
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| Authors: | Yu Mingqing Hu Yanqun Liu Zilong Zhang Cuiqun Wu Xirui Family Planning Research Institute Tongji Medical University WuhanZhou Houlum Lao Huixian Liu Yunhua |
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| Institution: | Yu Mingqing,Hu Yanqun,Liu Zilong,Zhang Cuiqun,Wu Xirui Family Planning Research Institute,Tongji Medical University,WuhanZhou Houlum,Lao Huixian,Liu YunhuaDepartment of Anatomy,Faculty of Basic MedicalSciences,Tongji Medical University,Wuhan |
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| Abstract: | After six to eight weeks of oral administration of gossypol acetic acid (30mg/kg/day for six days per week) to Wistar rats, the following changes were observed by transmission and scanning electron microscopic examination: swelling of the mitochondria of proximal and distal convoluted tubules, their cristae became not so clear. These changes are accompanied with alteration of lysosomes (in early stage increased in number and enlarged in volume, with polymorphic changes, then decreased in number and diminished in volume). Besides, swelling of the microvilli appeared in proximal convoluted tubules. Edema appeared also in the basal lamina of some convoluted tubules. No significant ultrastructural changes were observed in endothelial cells, basal lamina and podocytes in the. glomerular vessels. |
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| Keywords: | gossypol acetic acid renal proximal convoluted tubules renal distal convoluted tubules glomerular vessels endothelial cells |
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