| 代谢组学在药物滥用毒理学中的应用 |
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| 引用本文： | 雷啟芬,朱丹.代谢组学在药物滥用毒理学中的应用[J].航天医学与医学工程,2017,30(3). |
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| 作者姓名： | 雷啟芬 朱丹 |
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| 作者单位： | 中央民族大学中国少数民族传统医学国家民委-教育部重点实验室,北京,100081 |
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| 摘 要： | 药物滥用产生的依赖性是一个世界性的社会问题,引起全社会的广泛关注。研究药物依赖产生的机制,有利于帮助涉毒人群戒断治疗。代谢组学近年来被广泛应用于毒理学领域,尤其是用于解释毒性产生的机制。本文综述代谢组学在药物滥用的急性或慢性毒性研究的应用,重点在于兴奋剂、阿片药物、以及近年来流行的前体药物。
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| 关 键 词： | 代谢组学 药物滥用 毒理学 急性毒性 慢性毒性 |
Application of Metabolomics on Toxicology of Drugs Abuse |
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| Lei Qifen,Zhu Dan.Application of Metabolomics on Toxicology of Drugs Abuse[J].Space Medicine & Medical Engineering,2017,30(3). |
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| Authors: | Lei Qifen Zhu Dan |
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| Abstract: | The dependence of drug abused produced is a worldwide social problem in recent years,and caused widespread concern in society.The mechanism on drug dependence formation was conducive to drug abuse population detoxification treatment.Metabolomics has been widely applied to toxicological fields,especially to elucidate the mechanism of action of toxicity.This review focused metabolomics application on the studies of chronic and acute toxicities of drugs of abuse like stimulants,opioids and the recently-distributed designer drugs. |
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| Keywords: | metabolomics drug abuse toxicology acute toxicity chronic toxicity |
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