Genetic variation in strains of zebrafish (Danio rerio) and the implications for ecotoxicology studies |
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Authors: | T S Coe P B Hamilton A M Griffiths D J Hodgson M A Wahab C R Tyler |
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Institution: | (1) Environmental and Molecular Fish Biology Group, University of Exeter, Exeter, UK;(2) Molecular Ecology and Evolution Group, University of Exeter, Exeter, UK;(3) Centre for Ecology and Conservation, University of Exeter Cornwall Campus, Penryn, UK;(4) Department of Fisheries Management, Bangladesh Agricultural University, Mymensingh, Bangladesh |
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Abstract: | There is substantial evidence that genetic variation, at both the level of the individual and population, has a significant
effect on behaviour, fitness and response to toxicants. Using DNA microsatellites, we examined the genetic variation in samples
of several commonly used laboratory strains of zebrafish, Danio rerio, a model species in toxicological studies. We compared the genetic variation to that found in a sample of wild fish from
Bangladesh. Our findings show that the wild fish were significantly more variable than the laboratory strains for several
measures of genetic variability, including allelic richness and expected heterozygosity. This lack of variation should be
given due consideration for any study which attempts to extrapolate the results of ecotoxicological laboratory tests to wild
populations. |
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Keywords: | Zebrafish Danio rerio Microsatellites Genetic variation |
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